Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium.
Identifieur interne : 000208 ( France/Analysis ); précédent : 000207; suivant : 000209Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium.
Auteurs : Dolores L Pez-Terrada [États-Unis] ; Rita Alaggio [Italie] ; Maria T. De Dávila [Argentine] ; Piotr Czauderna [Pologne] ; Eiso Hiyama [Japon] ; Howard Katzenstein [États-Unis] ; Ivo Leuschner [Allemagne] ; Marcio Malogolowkin [États-Unis] ; Rebecka Meyers [États-Unis] ; Sarangarajan Ranganathan [États-Unis] ; Yukichi Tanaka [Japon] ; Gail Tomlinson [États-Unis] ; Monique Fabrè [France] ; Arthur Zimmermann [Suisse] ; Milton J. Finegold [États-Unis]Source :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [ 1530-0285 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Hépatoblastome, Tumeurs du foie.
- Enfant, Humains, Hépatoblastome, Los Angeles, Pédiatrie, Tumeurs du foie.
English descriptors
- KwdEn :
- MESH :
- geographic : Los Angeles.
- classification : Hepatoblastoma, Liver Neoplasms.
- diagnosis : Hepatoblastoma, Liver Neoplasms.
- Child, Humans, Pediatrics.
Abstract
Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children's Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Société Internationale d'Oncologie Pédiatrique, Gesellschaft für Pädiatrische Onkologie und Hämatologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.
DOI: 10.1038/modpathol.2013.80
PubMed: 24008558
Affiliations:
- Allemagne, Argentine, France, Italie, Japon, Pologne, Suisse, États-Unis
- Canton de Berne, Géorgie (États-Unis), Pennsylvanie, Schleswig-Holstein, Texas, Utah, Wisconsin
- Berne, Kiel
- Université de Berne
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pubmed:24008558Le document en format XML
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De Dávila</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Patologia, Hospital de Pediatría Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Patologia, Hospital de Pediatría Prof. Dr. J.P. 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xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Natural Science Center for Basic Research and Development, Hiroshima University Hospital, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Katzenstein, Howard" sort="Katzenstein, Howard" uniqKey="Katzenstein H" first="Howard" last="Katzenstein">Howard Katzenstein</name><affiliation wicri:level="2"><nlm:affiliation>Aflac Cancer Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Leuschner, Ivo" sort="Leuschner, Ivo" uniqKey="Leuschner I" first="Ivo" last="Leuschner">Ivo Leuschner</name><affiliation wicri:level="3"><nlm:affiliation>Institut fur Pathologie, UNI-Klinikum Campus, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut fur Pathologie, UNI-Klinikum Campus, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Malogolowkin, Marcio" sort="Malogolowkin, Marcio" uniqKey="Malogolowkin M" first="Marcio" last="Malogolowkin">Marcio Malogolowkin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatric Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Oncology, Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Meyers, Rebecka" sort="Meyers, Rebecka" uniqKey="Meyers R" first="Rebecka" last="Meyers">Rebecka Meyers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatric Surgery, Primary Children's Medical Center, University of Utah, Salt Lake City, UT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Surgery, Primary Children's Medical Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Ranganathan, Sarangarajan" sort="Ranganathan, Sarangarajan" uniqKey="Ranganathan S" first="Sarangarajan" last="Ranganathan">Sarangarajan Ranganathan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Tanaka, Yukichi" sort="Tanaka, Yukichi" uniqKey="Tanaka Y" first="Yukichi" last="Tanaka">Yukichi Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pathology, Kanagawa Children's Medical Center, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pediatric Hematology-Oncology, University of Texas Health Science Center, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Hematology-Oncology, University of Texas Health Science Center, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Fabre, Monique" sort="Fabre, Monique" uniqKey="Fabre M" first="Monique" last="Fabrè">Monique Fabrè</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institut de Cancerologie Gustave Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Institut de Cancerologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Zimmermann, Arthur" sort="Zimmermann, Arthur" uniqKey="Zimmermann A" first="Arthur" last="Zimmermann">Arthur Zimmermann</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Pathology, University of Bern, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Finegold, Milton J" sort="Finegold, Milton J" uniqKey="Finegold M" first="Milton J" last="Finegold">Milton J. Finegold</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc</title><idno type="eISSN">1530-0285</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Hepatoblastoma (classification)</term><term>Hepatoblastoma (diagnosis)</term><term>Humans</term><term>Liver Neoplasms (classification)</term><term>Liver Neoplasms (diagnosis)</term><term>Los Angeles</term><term>Pediatrics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Hépatoblastome ()</term><term>Hépatoblastome (diagnostic)</term><term>Los Angeles</term><term>Pédiatrie</term><term>Tumeurs du foie ()</term><term>Tumeurs du foie (diagnostic)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Los Angeles</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepatoblastoma</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hepatoblastoma</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hépatoblastome</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Pediatrics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Hépatoblastome</term><term>Los Angeles</term><term>Pédiatrie</term><term>Tumeurs du foie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children's Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Société Internationale d'Oncologie Pédiatrique, Gesellschaft für Pädiatrische Onkologie und Hämatologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>France</li><li>Italie</li><li>Japon</li><li>Pologne</li><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Berne</li><li>Géorgie (États-Unis)</li><li>Pennsylvanie</li><li>Schleswig-Holstein</li><li>Texas</li><li>Utah</li><li>Wisconsin</li></region><settlement><li>Berne</li><li>Kiel</li></settlement><orgName><li>Université de Berne</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="L Pez Terrada, Dolores" sort="L Pez Terrada, Dolores" uniqKey="L Pez Terrada D" first="Dolores" last="L Pez-Terrada">Dolores L Pez-Terrada</name></region><name sortKey="Finegold, Milton J" sort="Finegold, Milton J" uniqKey="Finegold M" first="Milton J" last="Finegold">Milton J. Finegold</name><name sortKey="Katzenstein, Howard" sort="Katzenstein, Howard" uniqKey="Katzenstein H" first="Howard" last="Katzenstein">Howard Katzenstein</name><name sortKey="Malogolowkin, Marcio" sort="Malogolowkin, Marcio" uniqKey="Malogolowkin M" first="Marcio" last="Malogolowkin">Marcio Malogolowkin</name><name sortKey="Meyers, Rebecka" sort="Meyers, Rebecka" uniqKey="Meyers R" first="Rebecka" last="Meyers">Rebecka Meyers</name><name sortKey="Ranganathan, Sarangarajan" sort="Ranganathan, Sarangarajan" uniqKey="Ranganathan S" first="Sarangarajan" last="Ranganathan">Sarangarajan Ranganathan</name><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name></country><country name="Italie"><noRegion><name sortKey="Alaggio, Rita" sort="Alaggio, Rita" uniqKey="Alaggio R" first="Rita" last="Alaggio">Rita Alaggio</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="De Davila, Maria T" sort="De Davila, Maria T" uniqKey="De Davila M" first="Maria T" last="De Dávila">Maria T. De Dávila</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Czauderna, Piotr" sort="Czauderna, Piotr" uniqKey="Czauderna P" first="Piotr" last="Czauderna">Piotr Czauderna</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Hiyama, Eiso" sort="Hiyama, Eiso" uniqKey="Hiyama E" first="Eiso" last="Hiyama">Eiso Hiyama</name></noRegion><name sortKey="Tanaka, Yukichi" sort="Tanaka, Yukichi" uniqKey="Tanaka Y" first="Yukichi" last="Tanaka">Yukichi Tanaka</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Leuschner, Ivo" sort="Leuschner, Ivo" uniqKey="Leuschner I" first="Ivo" last="Leuschner">Ivo Leuschner</name></region></country><country name="France"><noRegion><name sortKey="Fabre, Monique" sort="Fabre, Monique" uniqKey="Fabre M" first="Monique" last="Fabrè">Monique Fabrè</name></noRegion></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Zimmermann, Arthur" sort="Zimmermann, Arthur" uniqKey="Zimmermann A" first="Arthur" last="Zimmermann">Arthur Zimmermann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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